Isopropylamine → HCID 49804465, compound

Participants

Reaction Steps

A mixture of 6-(5-methyl-3-propyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (290 mg, 1.0 mmol), isopropylamine (71 mg, 1.2 mmol) and TBD (42 mg, 0.30 mmol) was stirred for 15 h at ambient temperature under argon. The reaction mixture was concentrated onto silica then purified by chromatography (silica, 0 to 60% ethyl acetate in heptane) to give the title compound (95 mg, 30%) as a white solid after trituration with diisopropyl ether. MS: m/e=318.1 [M+H]+.

Provenance & Evidence