4-Aminotetrahydropyran → HCID 49804753, compound

Participants

Reaction Steps

As described for example 1e, 6-(5-methyl-3-propyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (145 mg, 0.50 mmol) was converted, using 4-aminotetrahydropyran instead of isopropylamine, to the title compound (35 mg, 19%) which was obtained as a white solid after purification by chromatography (silica, 0-6% methanol in dichloromethane) and after trituration with diisopropyl ether. MS: m/e=360.3 [M+H]+.

Provenance & Evidence