4-Aminotetrahydropyran → HCID 49804755, compound

Participants

Reaction Steps

As described for example 1e, 6-[5-methyl-3-(3,3,3-trifluoro-propyl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (215 mg, 0.62 mmol) was converted, using 4-aminotetrahydropyran instead of isopropylamine, to the title compound (26 mg, 10%) which was obtained as a white solid after purification by chromatography (silica, 0 to 60% ethyl acetate in heptane) and trituration with ethyl acetate and hexane. MS: m/e=414.3 [M+H]+.

Provenance & Evidence