Cyclopropylamine → 6-((3-Butyl-5-methyl-isoxazol-4-yl)methoxy)-N-cyclopropyl-nicotinamide

Participants

Reaction Steps

As described for example 5d, 6-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (537 mg, 1.5 mmol) was converted, using cyclopropylamine instead of isopropylamine, to the title compound (85 mg, 17%) which was obtained as a white solid after purification by chromatography (silica, 0 to 50% ethyl acetate in heptane). MS: m/e=330.4 [M+H]+.

Provenance & Evidence