2-Amino-2-methyl-1-propanol → 6-((3-Butyl-5-methyl-isoxazol-4-yl)methoxy)-N-(2-hydroxy-1,1-dimethyl-ethyl)-nicotinamide

Participants

Reaction Steps

As described for example 5d, 6-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (537 mg, 1.5 mmol) was converted, using 2-amino-2-methyl-1-propanol instead of isopropylamine, to the title compound (155 mg, 29%) which was obtained as a white solid after purification by chromatography (silica, 0 to 60% ethyl acetate in heptane). MS: m/e=362.4 [M+H]+.

Provenance & Evidence