2-Aminopropanol → Rac-6-((3-butyl-5-methyl-isoxazol-4-yl)methoxy)-n-(2-hydroxy-1-methyl-ethyl)-nicotinamide

Participants

Reaction Steps

A mixture of 6-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (250 mg, 0.82 mmol), rac-2-amino-1-propanol (63 mg, 0.84 mmol) and TBD (29 mg, 0.21 mmol) was stirred for 15 h at room temperature under argon. The reaction mixture was concentrated onto silica then purified by chromatography (silica, 0 to 4% methanol in dichloromethane) to give the title compound (145 mg, 60%) as a white solid after trituration with diisopropyl ether. MS: m/e=348.3 [M+H]+.

Provenance & Evidence