Oxolan-3-amine → HCID 49800453, compound

Participants

Reaction Steps

As described for example 5d, 6-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (150 mg, 0.49 mmol) was converted, using tetrahydrofuran-3-amine instead of isopropylamine, to the title compound (120 mg, 68%) which was obtained as a white solid after purification by chromatography (silica, 0 to 5% methanol in dichloromethane). MS: m/e=360.4 [M+H]+.

Provenance & Evidence