1-Amino-2-propanol → HCID 49800732, compound

Participants

Reaction Steps

As described for example 9, 6-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (150 mg, 0.49 mmol) was converted, using rac-1-amino-2-propanol instead of rac-2-amino-1-propanol, to the title compound (5 mg, 3%) which was obtained as a yellow oil after purification by chromatography (silica, 0 to 6% methanol in dichloromethane). MS: m/e=348.3 [M+H]+.

Provenance & Evidence