1,1,1-Trifluoro-2-propanamine → 6-((3-Butyl-5-methyl-isoxazol-4-yl)methoxy)-n-((s)-2,2,2-trifluoro-1-methyl-ethyl)-nicotinamide

Participants

Reaction Steps

As described for example 19b, 6-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid (100 mg, 0.34 mmol) was converted, using L-2,2,2-trifluoro-1-(methyl)ethylamine (ABCR AB146651) instead of L-2,2,2-trifluoro-1-(methyl)ethylamine (ABCR F07820EFA), to the title compound (81 mg, 61%) which was obtained as a light yellow oil after purification by chromatography (silica, heptane:ethyl acetate=1:0 to 2:1). MS: m/e=384.3 [M−H]−.

Provenance & Evidence