1-Methylcyclopropanamine → 6-((3-Butyl-5-methyl-isoxazol-4-yl)methoxy)-N-(1-methyl-cyclopropyl)-nicotinamide

Participants

Reaction Steps

As described for example 19b, 6-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid (100 mg, 0.34 mmol) was converted, using 1-methylcyclopropylamine instead of L-2,2,2-trifluoro-1-(methyl)ethylamine, to the title compound (83 mg, 70%) which was obtained as a white solid after purification by chromatography (silica, heptane:ethyl acetate=1:0 to 2:1). MS: m/e=342.3 [M−H]−.

Provenance & Evidence