Azetidine → Azetidin-1-yl-[6-((3-butyl-5-methyl-isoxazol-4-yl)methoxy)-pyridin-3-yl]-methanone

Participants

Reaction Steps

As described for example 19b, 6-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid (100 mg, 0.34 mmol) was converted, using azetidine instead of L-2,2,2-trifluoro-1-(methyl)ethylamine, to the title compound (45 mg, 39%) which was obtained as a light yellow oil after purification by chromatography (silica, heptane:ethyl acetate=1:0 to 2:1). MS: m/e=330.3 [M+H]+.

Provenance & Evidence