6-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester → HCID 49801024, compound

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Reaction Steps

As described for example 5d, 6-(3-butyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (200 mg, 0.69 mmol) was converted, instead of 6-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester, to the title compound (200 mg, 91%) which was obtained as a light brown solid after purification by chromatography (silica, 40 to 60% ethyl acetate in heptane). MS: m/e=318.3 [M+H]+.

Provenance & Evidence