Ethanamine, 2,2,2-trifluoro- → HCID 49801025, compound

Participants

Reaction Steps

As described for example 25e, 6-(3-butyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (200 mg, 0.69 mmol) was converted, using 2,2,2,-trifluoroethylamine instead of isopropylamine, to the title compound (170 mg, 69%) which was obtained as a white solid after purification by chromatography (silica, 30 to 50% ethyl acetate in heptane). MS: m/e=358.1 [M+H]+.

Provenance & Evidence