4-Aminotetrahydropyran → HCID 49801026, compound

Participants

Reaction Steps

As described for example 25e, 6-(3-butyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (200 mg, 0.69 mmol) was converted, using 4-aminotetrahydropyran instead of isopropylamine, to the title compound (180 mg, 73%) which was obtained as a white solid after purification by chromatography (silica, 40 to 60% ethyl acetate in heptane). MS: m/e=360.2 [M+H]+.

Provenance & Evidence