Isopropylamine → HCID 49801028, compound

Participants

Reaction Steps

As described for example 9, 6-[5-methyl-3-(1-methyl-butyl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (200 mg, 0.63 mmol), instead of 6-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester, was converted using isopropylamine instead of rac-2-amino-1-propanol, to the title compound (40 mg, 17%) which was obtained as a colourless oil after purification by chromatography (silica, 0 to 5% methanol in dichloromethane). MS: m/e=346.4 [M+H]

Provenance & Evidence