Cyclopropylamine → HCID 49801307, compound

Participants

Reaction Steps

As described for example 31e, 6-(3-cyclohexyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (708 mg, 1.5 mmol) was converted, using cyclopropylamine instead of isopropylamine, to the title compound (219 mg, 41%) which was obtained as a white solid after purification by chromatography (silica, 0 to 60% ethyl acetate in heptane). MS: m/e=356.3 [M+H]+.

Provenance & Evidence