4-Aminotetrahydropyran → HCID 49801308, compound

Participants

Reaction Steps

As described for example 31e, 6-(3-cyclohexyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (472 mg, 1.0 mmol) was converted, using 4-aminotetrahydropyran instead of isopropylamine, to the title compound (155 mg, 39%) which was obtained as a white solid after purification by chromatography (silica, 0 to 70% ethyl acetate in heptane). MS: m/e=400.3 [M+H]+.

Provenance & Evidence