2-Amino-2-methyl-1-propanol → HCID 49801310, compound

Participants

Reaction Steps

As described for example 31e, 6-(3-cyclohexyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (708 mg, 1.5 mmol) was converted, using 2-amino-2-methyl-1-propanol instead of isopropylamine, to the title compound (340 mg, 58%) which was obtained as a white solid after purification by chromatography (silica, 0 to 4% methanol in dichloromethane). MS: m/e=388.4 [M+H]+.

Provenance & Evidence