反应详情

温度

50 °C

A mixture of 6-(3-cyclohexyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (500 mg, 1.1 mmol), rac-2-amino-1-propanol (95 mg, 1.3 mmol) and TBD (44 mg, 0.31 mmol) was heated at 50° C. for 15 h under argon. The reaction mixture was concentrated onto silica then purified by chromatography (silica, 0 to 5% methanol in dichloromethane) to give the title compound (290 mg, 73%) as a white solid. MS: m/e=374.4 [M+H]+.

1. concentrationThe reaction mixture was concentrated onto silica
2. customthen purified by chromatography (silica, 0 to 5% methanol in dichloromethane)