L-Alaninol → HCID 49801312, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-[5-methyl-3-(tetrahydro-pyran-4-yl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (100 mg, 0.3 mol), S-(+)-2-amino-1-propanol (28.8 μL, 0.36 mmol) and TBD (12.8 mg, 0.09 mmol) was heated at 50° C. for 18 h under argon. The reaction mixture was concentrated onto silica then purified by chromatography (silica, 0 to 15% methanol in ethyl acetate) to give the title compound (30 mg, 27%) as a white solid. MS: m/e=374.4 [M+H]+.

Provenance & Evidence