Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 2-((1,1-Dimethylethyl)imino)-N,N-diethylhexahydro-1,3-dimethyl-2lambda5-1,3,2-diazaphosphorin-2-amine | HCID 3513851 | — |
| Reactant | 1254962-88-3 | HCID 66643698 | — |
| Product | HCID 66643555 | HCID 66643555 | 26.1% |
Reaction Steps
A mixture containing 3-bromo-5-methyl-isoxazole-4-carboxylic acid ethyl ester (5.0 g, 18.8 mmol), pyrrolidine (13.37 g, 188 mmol) and BEMP (10.53 g, 37.6 mmol) was heated in the microwave at 180° C. for 10 min. The mixture was then extracted with ethyl acetate, dried over potassium sulphate, filtered and evaporated. Purification by chromatography (silica, ethyl acetate:methanol 1:9 to 3:7) afforded the title compound (1.1 g, 21%) as a yellow oil. MS: m/e=225.3 [M]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08357703B2 |
|---|
| Source dataset | uspto-grants-2013_01 |
|---|
| ORD ID | ord-96d9ebd4b59a4ce783e1be6c97a829d2 |
|---|
| Source note | uspto-grants-2013_01 |
|---|
