4-Aminotetrahydropyran → HCID 49801609, compound

Participants

Reaction Steps

As described for example 40f, 6-(5-methyl-3-pyrrolidin-1-yl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (100 mg, 0.28 mmol), was converted, using 4-aminotetrahydropyran instead of isopropylamine, to the title compound (30 mg, 49%) which was obtained as a white solid after purification by chromatography (silica, 40 to 90% ethyl acetate in heptane). MS: m/e=387.2 [M+H]+.

Provenance & Evidence