Thionyl Chloride → HCID 66643618, compound

HRID 1807541Notes

Reaction equation

HRID 1807541 reaction equation
[CH2:1]([C:5]1[C:9]([CH2:10]O)=[C:8]([CH3:12])[O:7][N:6]=1)[CH2:2][CH2:3][CH3:4].S(Cl)([Cl:15])=O>ClCCl>[CH2:1]([C:5]1[C:9]([CH2:10][Cl:15])=[C:8]([CH3:12])[O:7][N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 66599297(3-Butyl-5-methyl-isoxazol-4-yl)-methanol

Product 1

HCID 66643618HCID 66643618, compoundYield 88.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (3-butyl-5-methyl-isoxazol-4-yl)-methanol (1.00 g, 5.9 mmol) in dichloromethane (10 mL) was added thionyl chloride (1.41 g, 11.8 mmol) dropwise at 0° C. After 1 h, the reaction mixture was evaporated to afford the title compound (980 mg, 88%) as a light brown liquid. MS: m/e=208.1 [M+H]+.

Workup

  1. customthe reaction mixture was evaporated

Sources & evidence

ORD record
ord-5c1e1c8677574487b19b92c7717afab4
Source dataset
uspto-grants-2013_01
Patent number
US08357703B2

Reaction notes

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