HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester → 6-[(3-Butyl-5-methyl-isoxazol-4-ylmethyl)-amino]-N-isopropyl-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester | HCID 66599158 | — |
| Reactant | Methyl 6-(((3-butyl-5-methylisoxazol-4-yl)methyl)amino)nicotinate | HCID 66643788 | — |
| Product | 6-[(3-Butyl-5-methyl-isoxazol-4-ylmethyl)-amino]-N-isopropyl-nicotinamide | HCID 49801610 | 70% |
Reaction Steps
As described for example 5d, 6-[(3-butyl-5-methyl-isoxazol-4-ylmethyl)-amino]-nicotinic acid methyl ester (90 mg, 0.3 mmol) was converted, instead of 6-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester, to the title compound (69 mg, 70%) which was obtained as a white foam after purification by chromatography (silica, 0 to 7% methanol in dichloromethane). MS: m/e=331.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08357703B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-a8b6b7458bc84d2b886562c740a67b7e |
| Source note | uspto-grants-2013_01 |