反应详情

温度

50 °C

A mixture of 6-[(3-butyl-5-methyl-isoxazol-4-ylmethyl)-amino]-nicotinic acid methyl ester (90 mg, 0.3 mmol), rac-2-amino-1-propanol (27 mg, 0.36 mmol) and TBD (12 mg, 0.09 mmol) was heated at 50° C. for 4 h under argon. The reaction mixture was concentrated onto silica then purified by chromatography (silica, 0 to 7% methanol in ethyl acetate) to give the title compound (55 mg, 54%) as a colourless oil. MS: m/e=347.3 [M+H]+.

1. concentrationThe reaction mixture was concentrated onto silica
2. customthen purified by chromatography (silica, 0 to 7% methanol in ethyl acetate)