4-Methylpiperidine-1-carbonyl Chloride → HCID 68454533, compound

HRID 1807563Notes

Reaction equation

HRID 1807563 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[N:8]=[C:7]2[NH:9][N:10]=[C:11]([OH:12])[C:6]2=[CH:5][CH:4]=1.[CH3:15][CH:16]1[CH2:21][CH2:20][N:19]([C:22](Cl)=[O:23])[CH2:18][CH2:17]1>>[CH3:15][CH:16]1[CH2:21][CH2:20][N:19]([C:22]([O:12][C:11]2[C:6]3[C:7](=[N:8][C:3]([C:2]([F:13])([F:1])[F:14])=[CH:4][CH:5]=3)[N:9]([C:22]([N:19]3[CH2:20][CH2:21][CH:16]([CH3:15])[CH2:17][CH2:18]3)=[O:23])[N:10]=2)=[O:23])[CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 152215164-Methylpiperidine-1-carbonyl ChlorideHCID 178518964HCID 178518964, compound

Product 1

HCID 68454533HCID 68454533, compound

Procedure

In analogy to example, 1, 120 mg (0.59 mmol) of 6-trifluoromethyl-1H-pyrazolo-[3,4-b]pyridin-3-ol were reacted with 143.3 mg (0.89 mmol) of 4-methylpiperidine-1-carbonyl chloride. Yield: 71 mg (26%), M+H+: 454.27.

Sources & evidence

ORD record
ord-796f65421c6a49cda5592082dbd81b13
Source dataset
uspto-grants-2013_01
Patent number
US08357698B2

Reaction notes

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