HRID1807637

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)c1ccc2c(C3CCCCC3)c(-c3ccccc3OCC(=O)N(C)CCCCN(C)S(N)(=O)=O)n(C)c2c1

HCID58317795

未命名化合物

结构：CN(CCOCCN(C)S(N)(=O)=O)C(=O)COc1ccccc1-c1c(C2CCCCC2)c2ccc(C(=O)O)cc2n1C

HCID58317827

未命名化合物

PRODUCTS

生成物

结构：CN(CCCCN(C)S(N)(=O)=O)C(=O)COc1ccccc1-c1c(C2CCCCC2)c2ccc(C(=O)O)cc2n1C

HCID58317821

未命名化合物

收率 78%

PROCEDURE

实验过程

3-cyclohexyl-1-methyl-2-{2-[2-(methyl {4-[methyl(sulfamoyl)amino]butyl}amino)-2-oxoethoxy]phenyl}-1H-indole-6-carboxylic acid 13 was synthesized in 78% yield from intermediate 12 following the procedure reported for the synthesis of intermediate 8: m/z=585 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b0a124e1b2464f7e8b39cc9af67c59d8
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08357687B2
来源说明: uspto-grants-2013_01

反应 SMILES

[CH:1]1([C:7]2[C:15]3[C:10](=[CH:11][C:12]([C:16]([O:18]C)=[O:17])=[CH:13][CH:14]=3)[N:9]([CH3:20])[C:8]=2[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[O:27][CH2:28][C:29]([N:31]([CH3:42])[CH2:32][CH2:33][CH2:34][CH2:35][N:36]([CH3:41])[S:37](=[O:40])(=[O:39])[NH2:38])=[O:30])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1(C2C3C(=CC(C(O)=O)=CC=3)N(C)C=2C2C=CC=CC=2OCC(N(C)CCOCCN(C)S(=O)(=O)N)=O)CCCCC1>>[CH:1]1([C:7]2[C:15]3[C:10](=[CH:11][C:12]([C:16]([OH:18])=[O:17])=[CH:13][CH:14]=3)[N:9]([CH3:20])[C:8]=2[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[O:27][CH2:28][C:29]([N:31]([CH3:42])[CH2:32][CH2:33][CH2:34][CH2:35][N:36]([CH3:41])[S:37](=[O:39])(=[O:40])[NH2:38])=[O:30])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1