HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-{2-[3-cyclohexyl-6-(1H-imidazol-1-ylcarbonyl)-1-methyl-1H-indol-2-yl]phenoxy}-N-methyl-N-(2-{2-[methyl(sulfamoyl)amino]ethoxy}ethyl)acetamide → 2-{2-[3-cyclohexyl-6-(1H-imidazol-1-ylcarbonyl)-1-methyl-1H-indol-2-yl]phenoxy}-N-methyl-N-{4-[methyl(sulfamoyl)amino]butyl}acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-{2-[3-cyclohexyl-6-(1H-imidazol-1-ylcarbonyl)-1-methyl-1H-indol-2-yl]phenoxy}-N-methyl-N-(2-{2-[methyl(sulfamoyl)amino]ethoxy}ethyl)acetamide | HCID 58317816 | — |
| Reactant | 3-cyclohexyl-1-methyl-2-{2-[2-(methyl {4-[methyl(sulfamoyl)amino]butyl}amino)-2-oxoethoxy]phenyl}-1H-indole-6-carboxylic acid | HCID 58317821 | — |
| Product | 2-{2-[3-cyclohexyl-6-(1H-imidazol-1-ylcarbonyl)-1-methyl-1H-indol-2-yl]phenoxy}-N-methyl-N-{4-[methyl(sulfamoyl)amino]butyl}acetamide | HCID 58317837 | 92% |
Reaction Steps
2-{2-[3-cyclohexyl-6-(1H-imidazol-1-ylcarbonyl)-1-methyl-1H-indol-2-yl]phenoxy}-N-methyl-N-{4-[methyl(sulfamoyl)amino]butyl}acetamide 14 was synthesized in 92% yield from intermediate 13 following the procedure reported for the synthesis of intermediate 9: m/z=635 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08357687B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-e619a7dc37604cb1b573b53bde7530a4 |
| Source note | uspto-grants-2013_01 |