Methyl iodide → HCID 86654679, compound

Participants

Reaction Steps

To a solution of tent-butyl (5-{[(2-nitrophenyl)sulfonyl]amino}pentyl)carbamate 55 (32.6 g, 84 mmol) in acetone (300 mL) was added potassium carbonate (23.2 g, 168 mmol). The resulting mixture was stirred at room temperature for 30 minutes then methyl iodide (17.88 g, 126 mmol) was added drop wise. The resulting mixture was stirred at room temperature overnight. The reaction mixture was poured in water and dichloromethane was added. The organic layer was separated and successively dried over MgSO4 filtered and concentrated. The residue was triturated with di-isopropyl ether to yield 31.6 g 93% of tent-butyl (5-{methyl[(2-nitrophenyl)sulfonyl]amino}pentyl)carbamate 56 as a white powder m/z 402 [M+H]+.

Provenance & Evidence