Ammonia → HCID 57420320, compound

HRID 1807656Notes

Reaction equation

HRID 1807656 reaction equation
[CH3:1][N:2]([CH2:4][C@@:5]12[CH2:17][CH2:16][CH2:15][N:6]1[C@@H](C(Cl)(Cl)Cl)[O:8][C:9]2=O)[CH3:3].[NH3:18]>CO>[CH3:1][N:2]([CH2:4][C@@:5]1([C:9]([NH2:18])=[O:8])[CH2:17][CH2:16][CH2:15][NH:6]1)[CH3:3]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 58092775HCID 58092775, compound

Product 1

HCID 57420320HCID 57420320, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of (3R,7aR)-7a-dimethylaminomethyl-3-trichloromethyl-tetrahydro-pyrrolo[1,2-c]oxazol-1-one (Stage H.1, 0.26 g) and 7 M ammonia in MeOH (4 mL) was heated at 50° C. for 3 days in a sealed vessel. The cooled RM was then evaporated to give the title compound as a brown oil which was used without further purification. MS: M+H=172.1.

Workup

  1. customThe cooled RM was then evaporated

Sources & evidence

ORD record
ord-870c99b0c69247a09faf1a3493441a4d
Source dataset
uspto-grants-2013_01
Patent number
US08357707B2

Reaction notes

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