反应详情

温度

50 °C

A mixture of (3R,7aR)-7a-dimethylaminomethyl-3-trichloromethyl-tetrahydro-pyrrolo[1,2-c]oxazol-1-one (Stage H.1, 0.26 g) and 7 M ammonia in MeOH (4 mL) was heated at 50° C. for 3 days in a sealed vessel. The cooled RM was then evaporated to give the title compound as a brown oil which was used without further purification. MS: M+H=172.1.

1. customThe cooled RM was then evaporated