Ammonia → HCID 53890660, compound

HRID 1807658Notes

Reaction equation

HRID 1807658 reaction equation
[OH:1][CH2:2][C@@:3]12[CH2:15][CH2:14][CH2:13][N:4]1[C@@H](C(Cl)(Cl)Cl)[O:6][C:7]2=O.[NH3:16].CO>>[OH:1][CH2:2][C@@:3]1([C:7]([NH2:16])=[O:6])[CH2:15][CH2:14][CH2:13][NH:4]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 887MethanolHCID 58092734HCID 58092734, compound

Product 1

HCID 53890660HCID 53890660, compound

Conditions

Temperature
75 °C

Procedure

(3R,7aR)-7a-Hydroxymethyl-3-trichloromethyl-tetrahydro-pyrrolo[1,2-c]oxazol-1-one (Stage J.1, 308 mg, 1.122 mmol) was added to 7 M ammonia in MeOH (8.014 mL, 56.1 mmol) under argon and heated at 75° C. in a sealed vessel for 72 h and then evaporated to give the title compound as a viscous pale brown oil which was used without further purification.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-58c661bb0415443a86570c38b8818d51
Source dataset
uspto-grants-2013_01
Patent number
US08357707B2

Reaction notes

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