HCID 58092727, compound → HCID 55291325, compound

(2S,3R)-3-Methyl-1-((S)-1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid amide (Stage P.1, 1.1 g, 4.76 mmol) and Pd on charcoal 10% (0.101 g, 0.947 mmol) in MeOH (20 mL) was shaken under a H2 atm. for 46 h at rt. The RM was then filtered through a Fluoropore Membrane Filter (0.2 μm FG) and evaporated. The residue was dissolved in DCM and evaporated to dryness to give the title compound as white crystals MS: M+H=129.0. 1H-NMR (d6-DMSO, 600 MHz): 7.34 (s, br,1H), 7.10 (s, br,1H), 3.48 (d, 1H), 3.0.2-2.97 (m, 1H), 2.80-2.75 (m, 1H), 2.35-2.28 (m, 1H), 1.88-1.81 (m, 1H), 1.39-1.32 (m, 1H), 0.83 (d, 3H).

1. filtrationThe RM was then filtered through a Fluoropore Membrane
2. filtrationFilter (0.2 μm FG)
3. customevaporated
4. dissolutionThe residue was dissolved in DCM
5. customevaporated to dryness

ORD record

ord-3a47028e13f2460595baffe5fd44f0d5

Source dataset

uspto-grants-2013_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08357707B2