1-Butanol → HCID 58092718, compound

Participants

Reaction Conditions

Reaction Steps

Concentrated HCl (0.3 ml) was added to a mixture of (2S,4S)-4-dimethylamino-pyrrolidine-2-carboxylic acid methyl ester dihydrochloride (400 mg) and 1-butanol (4 ml) and heated for 18 h at 115° C. After cooling the RM was evaporated then partitioned between DCM and aqueous NaHCO3 solution and the DCM layers dried and evaporated to give the title compound as a brown oil which was used without further purification.

Provenance & Evidence