HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → (2S,4S)-4-hydroxypyrrolidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | cis-4-Hydroxy-L-proline methyl ester hydrochloride | HCID 12764092 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (2S,4S)-4-hydroxypyrrolidine-2-carboxamide | HCID 2452260 | — |
Reaction Steps
A solution of (2S,4S)-4-hydroxy-pyrrolidine-2-carboxylic acid methyl ester hydrochloride (1 g) in a 7M solution of ammonia in MeOH (10 ml) was stirred for 18 h then evaporated and triturated with Et2O. The residue was dissolved in the minimum volume of hot MeOH and stood at 4° C. for 4 h. The title compound was isolated by filtration as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08357707B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-fd193be946c7456a9a2ca9cfd72b8df7 |
| Source note | uspto-grants-2013_01 |