HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1807695Generated: November 1, 2026
Phosphorus oxide (P4O10) → 3,3,3-Trifluoro-2,2-dimethyl-propionitrile
https://huagongshe.com/reaction/1807695
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxide (P4O10) | HCID 14812 | — |
| Reactant | 3,3,3-Trifluoro-2,2-dimethyl-propionamide | HCID 57516279 | — |
| Product | 3,3,3-Trifluoro-2,2-dimethyl-propionitrile | HCID 20767654 | — |
Reaction Steps
A mixture of 3,3,3-trifluoro-2,2-dimethyl-propionamide (Stage 44.4) (121.2 mmol) and phosphorus pentoxide (121.2 mmol) was slowly heated to 200° C. and the resulting distillate collected. The title compound was obtained as a colorless liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08357707B2 |
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| Source dataset | uspto-grants-2013_01 |
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| ORD ID | ord-361a407d862c4749a102d0c4ccf3caa6 |
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| Source note | uspto-grants-2013_01 |
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