4-Nitrobenzoic Acid → HCID 59175908, compound

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Reaction Steps

A mixture of methyl 3-(piperazin-1-ylmethyl)benzoate (2.47 g, 10.542 mmol), 4-nitrobenzoic acid (1.77 g, 10.542 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (3.03 g, 15.813 mmol), triethylamine (2.94 mL, 21.084 mmol) and acetonitrile (40 mL) were stirred together, at ambient temperature, for 4 hours before being concentrated under vacuum. The residue was dissolved in ethyl acetate, filtered, washed with water (×2) and treated with strong cation exchange column chromatography to afford the title compound (3.12 g). MS (ESI) m/z 384.3 [M+H]+

Provenance & Evidence