Hydrochloric Acid → HCID 59175857, compound

Participants

Reaction Steps

(4-(3-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)benzyl)piperazin-1-yl)(4-nitrophenyl)methanone (180 mg, 0.37 mmol), iron powder (205 mg, 3.66 mmol), 1 M hydrochloric acid (549 μL, 0.55 mmol) and isopropanol (10 mL) were stirred together, at ambient temperature, for 2 hours before being filtered and concentrated under vacuum. The residue was treated with strong cation exchange column chromatography and purified by silica chromatography (eluting with a solvent gradient from dichloromethane to 4% methanol/dichloromethane). The product was recrystallised from benzonitrile to afford the title compound (131 mg). MS (ESI) m/z 462.1 [M+H]+

Provenance & Evidence