Isopropylamine → HCID 59175889, compound

Participants

Reaction Steps

(4-Aminophenyl)(4-(3-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)-piperazin-1-yl)methanone (131 mg, 0.28 mmol) was dissolved in acetonitrile (5 mL) and treated with 4-nitrophenyl carbonochloridate (57.8 mg, 0.29 mmol). This was stirred at room temperature for 1 hour before isopropylamine (0.121 mL, 1.42 mmol) was added. The reaction was stirred for a further 2 hours at room temperature, filtered and concentrated under vacuum. The mixture was purified by HPLC and then treated with strong cation exchange column chromatography to afford the title compound (17.0 mg).

Provenance & Evidence