Cyclopropanemethanol → HCID 59175879, compound

Participants

Reaction Steps

(4-Amino-3-fluorophenyl)(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-benzyl)piperazin-1-yl)methanone (0.209 mmol, 0.1 g) and 4-nitrophenyl carbonochloridate (0.209 mmol, 0.042 g) were combined and stirred in dichloromethane (1 mL) at room temperature for 30 minutes. Cyclopropylmethanol (0.417 mmol, 0.030 g) and N,N-dimethylaminopyridine (0.003 g, 0.0209 mmol) were added and the reaction stirred at room temperature for 17 hours. The reaction was concentrated under vacuum and purified by acidic reverse phase HPLC to afford the title compound (22 mg).

Provenance & Evidence