Sodium Bicarbonate → HCID 86638551, compound

Participants

Reaction Steps

A mixture of (4-amino-3-chlorophenyl)(piperazin-1-yl)methanone (6.67 mmol, 1.6 g), 2-(4-(bromomethyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (6.67 mmol, 2.250 g), sodium hydrogencarbonate (20.02 mmol, 1.682 g) and sodium iodide (0.334 mmol, 0.050 g) in acetonitrile (50 mL) was stirred for 24 hours. The reaction was concentrated under reduced pressure and dichloromethane was added. The mixture was filtered and the filtrate was chromatographed on silica eluting with dichloromethane to dichloromethane/ethyl acetate to give the title compound (1.66 g).

Provenance & Evidence