Triethylamine → HCID 67059707, compound

Participants

Reaction Steps

To a stirred solution of 6-aminonicotinic acid (1 g, 7.24 mmol) in dimethylformamide (50 mL) was added 1-benzylpiperazine (1.258 mL, 1.276 g, 7.24 mmol), triethylamine (2.018 mL, 1.465 g, 14.48 mmol), 1-hydroxybenzotriazole hydrate (1.109 g, 7.24 mmol) and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (1.388 g, 7.24 mmol). After being stirred overnight at room temperature the reaction mixture was concentrated under vacuum. Purification by silica chromatography (eluting with 5% methanol/dichloromethane) gave the title compound (1.8 g).

Provenance & Evidence