HCID 67059654, compound → HCID 67059653, compound

Participants

Reaction Steps

1-(5-(4-Benzylpiperazine-1-carbonyl)pyridin-2-yl)-3-butylurea (58 mg, 0.147 mmol) and palladium on carbon 10% (15.61 mg, 0.015 mmol) were stirred in ethanol (2.5 mL containing 3 drops of 5M hydrochoric acid) under a hydrogen atmosphere at 5 bar at room temperature overnight. The mixture was filtered and the residue was taken up in dichloromethane/methanol and loaded on to a strong cation exchange column (2 g) and washed with dichloromethane/methanol. Elution of the column with 2M ammonia in methanol gave the title compound (44 mg).

Provenance & Evidence