Sodium Iodide → HCID 86638554, compound

Participants

Reaction Steps

1-Butyl-3-(5-(piperazine-1-carbonyl)pyridin-2-yl)urea (45 mg, 0.147 mmol), 2-(4-(bromomethyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (55 mg, 0.162 mmol), potassium carbonate (61 mg, 0.442 mmol) and sodium iodide (4 mg, 0.029 mmol) were stirred together in acetonitrile (1.5 mL) at reflux for 2 hours. After this time the mixture was cooled to room temperature and diluted with water and ethyl acetate. The organic layer was separated, dried and concentrated under reduced pressure. The residue was purified by silica chromatography eluting with 5% methanol in dichloromethane to give the title compound (29 mg).

Provenance & Evidence