反应详情

温度

100 °C

(4-Amino-3-fluorophenyl)(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperazin-1-yl)methanone (0.209 mmol, 0.1 g) and isocyanatobenzene (0.229 mmol, 0.025 mL, 0.027 g) were combined and heated in the microwave at 100° C. for 10 minutes. Further isocyanatobenzene (0.229 mmol, 0.025 mL, 0.027 g) was added and the reaction heated in the microwave for a further 10 minutes at 100° C. The reaction mixture was concentrated under reduced pressure and purified by acidic preparative HPLC to afford the title compound (71 mg). MS (ESI) m/z 599.0 [M+H]+

1. temperaturethe reaction heated in the microwave for a further 10 minutes at 100° C
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. custompurified by acidic preparative HPLC