Triethylamine → HCID 67059680, compound

Participants

Reaction Steps

4-Amino-3-fluorobenzoic acid (28.4 mmol, 4.40 g), 1-benzylpiperazine (28.4 mmol, 4.93 mL, 5 g) and triethylamine (85 mmol, 11.86 mL, 8.61 g) were stirred in dichloromethane at room temperature. 1-Propanephosphonic acid cyclic anhydride (42.6 mmol, 25.2 mL, 27.1 g, 50% solution in ethyl acetate) was added and the reaction mixture stirred at room temperature for 1 hour. The reaction mixture was washed with saturated sodium bicarbonate solution and concentrated under reduced pressure to afford the title compound (7.51 g). MS (ESI) m/z 314.1 [M+H]+

Provenance & Evidence