HCID 67059676, compound → HCID 67059704, compound

Participants

Reaction Steps

1-(4-(4-Benzylpiperazine-1-carbonyl)-2-fluorophenyl)-3-(2-cyano-2-methylpropyl)urea (4.12 mmol, 1.802 g) and 10% palladium on carbon (0.824 mmol, 0.877 g) were stirred in ethanol (40 mL) under a hydrogen atmosphere at 5 bar at room temperature overnight with a few drops of 5M hydrochloric acid. The catalyst was filtered off and the filtrate concentrated under reduced pressure to afford the title compound (1.033 g). MS (ESI) m/z 348.3 [M+H]+

Provenance & Evidence