Trifluoroacetic acid → (R)-1-(2-Fluoro-4-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperazine-1-carbonyl)phenyl)-3-(pyrrolidin-3-yl)urea

Participants

Reaction Steps

To a stirring solution of (R)-tert-butyl 3-(3-(2-fluoro-4-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperazine-1-carbonyl)phenyl)ureido)pyrrolidine-1-carboxylate (0.289 mmol, 200 mg) in dichloromethane (5 mL) was added trifluoroacetic acid (7.23 mmol, 824 mg) and the mixture allowed to stir at room temperature for 5 hours. The reaction mixture was purified by strong cation exchange column chromatography to afford the title compound (146 mg). MS (ESI) m/z 592.3 [M+H]+

Provenance & Evidence