Trifluoroacetic acid → 1,1,1,3,3,3-Hexafluoro-2-(4-(piperazin-1-ylmethyl)phenyl)propan-2-ol

Participants

Reaction Steps

To a solution of tert-butyl 4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperazine-1-carboxylate (16.09 mmol, 7.12 g) in dichloromethane (30 mL) was added trifluoroacetic acid (5 mL) and the reaction stirred at room temperature for 2 hours. The reaction mixture was concentrated under vacuum and purified by SCX chromatography to afford the title compound (3.5 g). MS (ESI) m/z 343.1 [M+H]+

Provenance & Evidence