反应详情

温度

80 °C

(4-Amino-3,5-difluorophenyl)(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperazin-1-yl)methanone (0.342 mmol, 170 mg) and phenyl pyridin-4-ylcarbamate (0.513 mmol, 110 mg) were combined in dioxane (2 mL) and heated to 80° C. overnight in a reactivial. The reaction mixture was concentrated under vacuum and the residue was purified by column chromatography (dichloromethane—4% methanol/dichloromethane) to afford title compound (45 mg). MS (ESI) m/z 618.3 [M+H]+

1. concentrationThe reaction mixture was concentrated under vacuum
2. customthe residue was purified by column chromatography (dichloromethane—4% methanol/dichloromethane)