反应详情

温度

80 °C

(4-Amino-3-(trifluoromethoxy)phenyl)(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperazin-1-yl)methanone (0.367 mmol, 200 mg) and phenyl pyridin-4-ylcarbamate (0.550 mmol, 118 mg) were combined in dioxane (2 mL) and heated to 80° C. overnight in a reactivial. The reaction mixture was concentrated under vacuum and the residue was purified by column chromatography (dichloromethane—4% methanol/dichloromethane) to afford title compound (11.7 mg). MS (ESI) m/z 666.3 [M+H]+

1. concentrationThe reaction mixture was concentrated under vacuum
2. customthe residue was purified by column chromatography (dichloromethane—4% methanol/dichloromethane)